Ketika Setiap Benturan Meninggalkan Bekas: Memahami Chronic Traumatic Encephalopathy

Chronic traumatic encephalopathy (CTE) adalah gangguan neurodegeneratif yang terjadi akibat cedera otak berulang, sering dijumpai pada atlet olahraga kontak. Gejala meliputi gangguan suasana hati, perilaku, dan kognisi. Diagnosis hanya dapat dipastikan setelah kematian. Pencegahan melalui pengurangan benturan kepala adalah satu-satunya langkah yang efektif saat ini.

https://legawa.com/2026/06/15/ketika-setiap-benturan-meninggalkan-bekas-memahami-chronic-traumatic-encephalopathy/

This brief highlights a novel cellular mechanism implicated in neurodegenerative risk, offering insight into how brain clearance processes may influence dementia trajectories. For mental health professionals, the finding illuminates potential links between neurobiology and cognitive-emotional functioning, underscoring the relevance of cellular-level factors in brain resilience and vulnerability.

Article Title: Scientists discover hidden brain cells that may stop Alzheimer’s tau buildup

Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/03/260307155945 dot htm

#neurodegeneration #tauopathy #tanycytes #brainhealth #alzheimersresearch

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🔊 New pre-print from David Butler and team!
"HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer's Disease"
#organoid #tauopathy #neurodegeneration #scRNAseq #Neuracell

biorxiv | https://zurl.co/iWU1

🔊 Happening today at #Tau2024: David Butler will present progress on development of #intrabody therapeutics to treat #tauopathy!

Session | Tauopathy-Directed Therapeutics
When | 2:45pm

@Alzheimer's Association

Liz Fisher is using astrocytes derived from human pluripotent #stemcells to study the affects of MAPT mutations on brain cell types. 😍

📷 hPSC-derived astrocyte in vitro. We think it looks like a crab. What do you see??

#tauopathy #astrocyte #FluorescentFriday

Frontotemporal degeneration (FTD) is associated with MAPT mutations, which affect tau protein. We use patient-derived 3D stem cell models to study neural development & degeneration.
Bertucci, et al. | https://zurl.co/JPD6

Cell lines used in this study are part of an outstanding resource collection produced with support from the #RainwaterCharitableFoundation. They are available to the research community through our #Neuracell core facility.
#RareDiseaseDay #tauopathy #endFTD #organoid

Did you miss Taylor's talk on an "Improved protocol for reproducible human cortical organoids for study of tauopathy" at #ECNP2023?

Check out the preprint on @biorxiv:
https://www.biorxiv.org/content/10.1101/2023.07.11.548571v1

#tauopathy #neurodegeneration #stemcell #organoid

I'm very happy to be part of this new work on #tauopathy 💫 Huge thanks 🙏 to 1st author Lydia Reinhardt 💪👏 and all other contributors: Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann @MaFu55, Dagmar Ehrnhoefer. @BioMed_X @dzne

🌎 https://doi.org/10.1016/j.nbd.2023.106126

Sally Temple joins a stellar program of speakers at the 2023 Gordon Conf. on Function Genomics of Human Brain Development & Disease this week, presenting on "Brain iPSC-derived organoids as a tool to model and combat #tauopathy."
#organoid #Alzheimers
https://www.grc.org/functional-genomics-of-human-brain-development-and-disease-conference/2023/
2023 Functional Genomics of Human Brain Development and Disease Conference GRC

The 2023 Gordon Research Conference on Functional Genomics of Human Brain Development and Disease will be held in Ventura, CA. Apply today to reserve your spot.