But our XLs also capture identities of + localise interfaces in >2000 binary PPIs! Many of these were known from previous high throughput #interactomics, but others were predicted, or a hop & skip away. Again - these are PPIs in native seqs, subcell locales, PTMs, cofactors.

Using #ColabFold, Xabier Vazquez Campos submitted >500 of our XLd PPIs + 400 random pairs to Multimer-v2 modelling. All types of XLd PPIs had larger predicted interfaces than those for random pairs. We also found diferences in interfaces for PPIs detected by diff interactome techniques.