PLOS BiologyMay 22
NK cells have a major role in the #tumor #microenvironment, but what do they do in #hepatocellular #carcinoma (HCC)? This study shows that MBL2 secreted by #HCC cells activates #NKcells via integrin β1–FAK–AKT signaling & reshapes the microenvironment @PLOSBiology https://plos.io/3PxgnHg
The EMBO JournalNov 27, 2023

GPNMB+Gal-3+ hepatic parenchymal cells promote immunosuppression and hepatocellular #carcinogenesis

#Profiling of #hepatocellular #carcinoma #HCC initiation and progression defines new molecular markers involved and emerging #malignant cell populations counteracting #immune surveillance

https://www.embopress.org/doi/full/10.15252/embj.2023114060

Gene OntologyDec 10, 2022
Here's a great paper from Hymel, Fisher, & Farazi @UNMC_PathMicro just published in BMC Cancer that used GO to look at the role of differential #methylation in #hepatocellular #carcinoma - congrats & thanks for citing the #geneontology! #CancerResearch