Faulty versions of the Foxp2 gene disrupt neurons’ ability to form synapses in brain regions involved in speech, a new study shows. Mutations of a gene called Foxp2 have been linked to a type of speech disorder called apraxia that makes it difficult to produce sequences of sound. A new study from
Scientists discover how mutations in a language gene produce speech deficits
Mutations of a #gene called #Foxp2 have been linked to a type of speech disorder called #apraxia that makes it difficult to produce sequences of sound.
A new study from MIT and National Yang Ming Chiao Tung University sheds light on how this gene controls the ability to produce speech.
In a study of mice, the researchers found that #mutations in Foxp2 disrupt the formation of dendrites and neuronal synapses in the brain’s #striatum, which plays important roles in the control of movement.
Mice with these mutations also showed impairments in their ability to produce the high-frequency sounds that they use to communicate with other mice.
Those malfunctions arise because Foxp2 mutations prevent the proper assembly of #motor #proteins, which move molecules within cells, the researchers found.
https://news.mit.edu/2023/scientists-discover-mutations-language-gene-speech-deficits-0503