Title: Enhancer Remodeling by OTX2 Directs Specification and Patterning of Mammalian Definitive Endoderm

πŸ” OTX2 is critical for definitive endoderm patterning.

#OTX2 #DevelopmentalBiology #Endoderm #GeneRegulation #Pub2Post https://tnyp.me/s3IJY0xx/m

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. This study reveals the role of Ca2+ dynamics in this process, showing that inhibition of #calcium transients causes DVE arrest
@PLOSBiology plos.io/4nHWxF4