Golgi-derived vesicles aid mitochondrial fission.
๐งช Golgi vesicles with PI(4)P enhance fission
๐ Arf1 & PI(4)KIIIฮฒ crucial for mitochondrial regulation
๐ฌ Deficiency alters mitochondrial morphology
โ PI(4)P pools assist division with actin polymerization
#MitochondrialFission #CellBiology https://dev.tnyp.me/a55QqHph/m
A Sympathetic Treatment for Obesity
โข๐ง Introduction of PEGyAMPH, a new non-CNS penetrative compound
โข๐ Maintains normothermia and spares cardiovascular side effects
โขโ๏ธ Promotes lipolysis and thermogenesis without affecting food intake
#AMPhDerivatives #ObesityTreatment #CellMetabolism https://dev.tnyp.me/qi70nPHW/m
Golgi vesicles modulate mitochondrial fission
๐ฌ Vesicles aid mitochondrial fission by interacting with organelles
๐ Arf1 silencing causes mitochondrial hyperfusion
๐ ER proximity suggests Arf1 role downstream of MERC formation
#CellBiology #MitochondrialFunction #ScientificResearch https://dev.tnyp.me/a55QqHph/m
Niacin alleviates systemic NAD+ deficiency in adult-onset mitochondrial myopathy.
๐ง Improves muscle strength
๐ช Increases mitochondrial biogenesis
๐ฉบ Enhances respiratory chain activity
๐ Reduces liver fat by 50%
๐ Boosts NAD+ levels up to 8x
Integration of NCD and HIV/AIDS Management in East Africa
๐ 13 of 31 policy documents suggest HIV and NCD service integration.
โ ๏ธ Limited evidence on integration effectiveness.
๐ Kenya, Tanzania, Rwanda, Uganda embrace policy integration.
#NCD #HIV #EastAfrica #HealthPolicy
https://dev.tnyp.me/Z5VST845/m
Background Low-income and middle-income countries are struggling to manage growing numbers of patients with chronic non-communicable diseases (NCDs), while services for patients with HIV infection are well established. There have been calls for integration of HIV and NCD services to increase efficiency and improve coverage of NCD care, although evidence of effectiveness remains unclear. In this review, we assess the extent to which National HIV and NCD policies in East Africa reflect the calls for HIV-NCD service integration.Methods Between April 2018 and December 2020, we searched for policies, strategies and guidelines associated with HIV and NCDs programmes in Burundi, Kenya, Rwanda, South Sudan, Tanzania and Uganda. Documents were searched manually for plans for integration of HIV and NCD services. Data were analysed qualitatively using document analysis.Results Thirty-one documents were screened, and 13 contained action plans for HIV and NCDs service integration. Integrated delivery of HIV and NCD care is recommended in high level health policies and treatment guidelines in four countries in the East African region; Kenya, Rwanda, Tanzania and Uganda, mostly relating to integrating NCD care into HIV programmes. The increasing burden of NCDs, as well as a move towards person-centred differentiated delivery of services for people living with HIV, is a factor in the recent adoption of integrated HIV and NCD service delivery plans. Both South Sudan and Burundi report a focus on building their healthcare infrastructure and improving coverage and quality of healthcare provision, with no reported plans for HIV and NCD care integration.Conclusion Despite the limited evidence of effectiveness, some East African countries have already taken steps towards HIV and NCD service integration. Close monitoring and evaluation of the integrated HIV and NCD programmes is necessary to provide insight into the associated benefits and risks, and to inform future service developments.
Integration of NCD and HIV/AIDS Management in East Africa
๐ 13 of 31 policy documents suggest HIV and NCD service integration.
โ ๏ธ Limited evidence on integration effectiveness.
๐ Kenya, Tanzania, Rwanda, Uganda embrace policy integration.
#NCD #HIV #EastAfrica #HealthPolicy
https://dev.tnyp.me/Z5VST845/m
Background Low-income and middle-income countries are struggling to manage growing numbers of patients with chronic non-communicable diseases (NCDs), while services for patients with HIV infection are well established. There have been calls for integration of HIV and NCD services to increase efficiency and improve coverage of NCD care, although evidence of effectiveness remains unclear. In this review, we assess the extent to which National HIV and NCD policies in East Africa reflect the calls for HIV-NCD service integration.Methods Between April 2018 and December 2020, we searched for policies, strategies and guidelines associated with HIV and NCDs programmes in Burundi, Kenya, Rwanda, South Sudan, Tanzania and Uganda. Documents were searched manually for plans for integration of HIV and NCD services. Data were analysed qualitatively using document analysis.Results Thirty-one documents were screened, and 13 contained action plans for HIV and NCDs service integration. Integrated delivery of HIV and NCD care is recommended in high level health policies and treatment guidelines in four countries in the East African region; Kenya, Rwanda, Tanzania and Uganda, mostly relating to integrating NCD care into HIV programmes. The increasing burden of NCDs, as well as a move towards person-centred differentiated delivery of services for people living with HIV, is a factor in the recent adoption of integrated HIV and NCD service delivery plans. Both South Sudan and Burundi report a focus on building their healthcare infrastructure and improving coverage and quality of healthcare provision, with no reported plans for HIV and NCD care integration.Conclusion Despite the limited evidence of effectiveness, some East African countries have already taken steps towards HIV and NCD service integration. Close monitoring and evaluation of the integrated HIV and NCD programmes is necessary to provide insight into the associated benefits and risks, and to inform future service developments.
Golgi-derived vesicles aid mitochondrial fission.
๐งฌ Golgi-vesicles enhance mitochondrial fission, driven by Arf1 and PI(4)KIIIb.
๐งซ PI(4)P vesicle recruitment is vital for Drp1-facilitated fission.
#MitochondrialFission #CellBiology
https://dev.https://tnyp.me/a55QqHph/m
the intestine
๐ Ketone bodies correlate with decreased Bifidobacterium growth
#KetogenicDiet #MicrobiomeImpact #ImmuneRegulation
https://dev.https://tnyp.me/6rlnCHJX/m
Policies for T2D and NCDs management during COVID-19 in Kenya & Tanzania.
๐ 17 documents reviewed (Kenya=10, Tanzania=7)
๐ Efforts to ensure care continuity noted
๐ Gaps existed in policies/guidelines
https://dev.https://tnyp.me/rdsfQp1E/m
