https://ntnuopen.ntnu.no/ntnu-xmlui/bitstream/handle/11250/2466061/Skorpen%2Bet%2Bal_2016_postscrpt.pdf?sequence=1 not a new paper. But I've been consistently surprised by how many doctors aren't even aware of this.

(I got grilled about supposedly being an addict when I had almost no response to fentanyl. All I knew at the time was that some members of the family had abnormal pain & analgesic responses.)

#opioids #deadsignaling #Arg181Cys
#painmanagement #analgesia #nociception

https://onlinelibrary.wiley.com/doi/10.1111/aas.12739