Mutations in
#microtubule regulatory protein Katnal2 have been linked to
#autism. This study finds that loss of Katnal2 in mice leads to autism-related phenotypes, driven in part by altered
#ciliary function in the lateral
#ventricles #PLOSBiology https://plos.io/4aezHNy
Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice
Mutations in the microtubule regulatory protein Katnal2 have been linked to autism. This study finds that loss of Katnal2 in mice leads to autism-related phenotypes, which are driven in part by altered ciliary function in the lateral ventricles.
A
#zebrafish model of
#scoliosis due to abnormal
#ciliary beating & ependymal polarity defects reveals that uneven distribution of
#Urotensin is a major cause of
#SpinalCurvature; abnormal Urotensin signaling is also seen in human patients
#PLOSBiology https://plos.io/3JbuKuX
Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish
Idiopathic scoliosis is the most common spinal deformity diagnosed in childhood or early adolescence. A zebrafish model of scoliosis due to abnormal ciliary beating and ependymal polarity defects reveals that uneven distribution of Urotensin neuropeptides is a major cause of spinal curvature; abnormal Urotensin signaling is also observed in human idiopathic scoliosis patients.
A
#zebrafish model of
#scoliosis due to abnormal
#ciliary beating & ependymal polarity defects reveals that uneven distribution of
#Urotensin is a major cause of
#SpinalCurvature; abnormal Urotensin signaling is also seen in human patients
#PLOSBiology https://plos.io/3JbuKuXEpendymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish
Idiopathic scoliosis is the most common spinal deformity diagnosed in childhood or early adolescence. A zebrafish model of scoliosis due to abnormal ciliary beating and ependymal polarity defects reveals that uneven distribution of Urotensin neuropeptides is a major cause of spinal curvature; abnormal Urotensin signaling is also observed in human idiopathic scoliosis patients.
A
#zebrafish model of
#scoliosis due to abnormal
#ciliary beating & ependymal polarity defects reveals that uneven distribution of
#Urotensin is a major cause of
#SpinalCurvature; abnormal Urotensin signaling is also seen in human patients
#PLOSBiology https://plos.io/3JbuKuXEpendymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish
Idiopathic scoliosis is the most common spinal deformity diagnosed in childhood or early adolescence. A zebrafish model of scoliosis due to abnormal ciliary beating and ependymal polarity defects reveals that uneven distribution of Urotensin neuropeptides is a major cause of spinal curvature; abnormal Urotensin signaling is also observed in human idiopathic scoliosis patients.
PLOS Biology
