Regular cannabinoid use is associated with concurrent increases in both pro-inflammatory and anti-inflammatory biomarkers, indicating a nuanced, context-dependent modulation of the immune system. Based on a large systematic review and meta-analysis of 46 studies with 54,382 participants, the pattern varies by study design, product type, recency of use, and population. No clear overall anti-inflammatory signal emerges, and evidence suggests the human immune response to cannabinoids is not uniformly suppressive.

This topic is of interest to psychology because it highlights how substance exposure can interface with immune signaling, potentially shaping mood, cognition, and psychiatric risk. The mixed inflammatory patterns emphasize the role of context, demographics, and product differences in health-related behavioral outcomes.

Article Title: Cannabinoid use is linked to both pro- and anti-inflammatory effects, massive review finds

Link to PsyPost Article: https://www.psypost dot org/cannabinoid-use-is-linked-to-both-pro-and-anti-inflammatory-effects-massive-review-finds/

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#Cannabinoids #Inflammation #Biomarkers #MentalHealth #CBD