#cGMP 12 is now on #ScienceOpen!
π Kassel, Germany | ποΈ June 18β20, 2026
π #CallforAbstracts: submit via ScienceOpen
β³ Deadline: April 2, 2026
π© Decisions/scheduling: May 2026
π Accepted abstracts published on ScienceOpen
πFull details in our blog post
Interesting, but the article is frustratingly vague about the mechanism of action.
The drug/MoA is probably the same as in this articleβ¬οΈ
"PnPP-19 potentiates erection, in vivo and ex vivo, via NO/cGMP pathway, does not affect sodium channels or rat heart, and shows no toxicity and low immunogenicity, what makes it a very promising candidate as a novel drug in the therapy of erectile dysfunction."
http://dx.doi.org/10.1016/j.juro.2015.06.081
~
NO is antimicrobial and it's possible this drug could be used for other purposes.
#NitricOxide #cGMP #vasodilators #DrugDevelopment #NaturalProducts #BZ371A
How the ancient messengers #cAMP and #cGMP deliver their messages.
#evolution #signalling #CNG_channels #membranes
https://phys.org/news/2023-05-ancient-messengers-cgmp-messages.html
Two highly similar molecules with essential but often contrasting signaling roles in most life forms exert their distinct effects through subtle differences in their bindings to their signaling partners, according to a new study led by researchers at Weill Cornell Medicine.
The idea of a set of quality metrics to gauge health is an excellent one. Still a long way to go
http://www.fdalawblog.net/2018/03/fdas-quality-metrics-program-the-sound-of-silence/
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