I've been deep into ONT basecalling model land as part of my recent archaea study, trying to see if it's worth it in the first place.

Here's read to phred map plot per hour of sequencing time- ONT SUP model on the left, and archaea tuned custom model on the right. Differences are certainly present - though how it propagates downstream is still an open question.

#bioinformatics #ONT #sequencing #basecaller