If you wish to go down this #VenousMalformation rabbit hole, which seemingly may include #sirolimus like every contemporary rabbit hole, see:

https://cdt.amegroups.com/article/view/12863/13421 which is https://pubmed.ncbi.nlm.nih.gov/28123976/

or

from Duke (not easy reading) https://www.minervamedica.it/en/journals/cardiovascular-surgery/article.php?cod=R37Y2021N05A0456&html=1&htmlID=TVRnYzBnenBQYVZpdXNIMGRJc3NQWUgwcUdmZHdQZm1Ia0F2MklqMGgrT3llREdxQWR0KzJyNEc2UDRpK3ptZw%3D%3D

or

from NYU: https://pubmed.ncbi.nlm.nih.gov/36561936/