Show threadThierry GalliMar 11, 2023
We found that the #Parkinson's disease related kinase #LRRK2 interacts with vesicular #SNAREs #VAMP4 and #VAMP7. #VAMP4 and #VAMP7 are required for proper processing and release of #Parkinson's disease #biomarkers #VGF as we found using #secretomics. We found late endosomal #secretion of #VGF together with #exosome markers like #CD63. We also developed a #rushassay to study #VGF #trafficking.
Thierry GalliMar 11, 2023
#Secretion of #VGF relies on the interplay between #LRRK2 and post-Golgi v-SNAREs #VAMP4 #VAMP7.
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00232-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723002322%3Fshowall%3Dtrue
Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs

Filippini et al. report the direct interaction of leucine-rich repeat kinase 2 (LRRK2) with the endosomal vesicular SNAREs VAMP4 and VAMP7. LRRK2, VAMP4, and VAMP7 regulate the secretion of the Parkinson’s disease biomarker VGF. They provide evidence for the role of LRRK2 in regulating unconventional secretion in the disease.

Cell Reports