@ChariteBerlin @MDC_Berlin

Really cool! This technique - tomoelastography - measures the mechanical stiffness of tissue.

"The cerebral cortex, i.e. the outer layer of the brain consisting of gray matter, is less stiff in people affected by MS than in healthy people. The animal model showed that this is due to changes in the perineuronal networks. Perineuronal nets form a network that surrounds the neurons and that loosens when there is inflammation." (translation by Google)

I have often wondered if there are differences in perineuronal nets in people with connective tissue disorders. Could this technique detect differences in people with EDS, for example? What about its use in other parts of the body, besides the brain? Perhaps the gut?

Also, changes in PNN occur with aging. Could this technique be used to measure brain aging?

#MultipleSclerosis #EDS #EhlersDanlos #ConnectiveTissue #Aging
#Tomoelastography #PerineuronalNets