Just my usual #NightshiftEditor reminder that when you are currently working on the (secondary) analysis of a data set and thinking of applying some regression modelling, here are some good resources:

#STROBE for reporting
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0040297

Thinking about confounders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447501/

Prediction vs causation
https://academic.oup.com/ije/article/49/6/2074/5831974

And avoiding the #Table2Fallacy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626058/

#HRQL

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration

In this explanatory and elaboration document Mattias Egger and colleagues provide the meaning and rationale of each checklist item on the STROBE Statement.

Reflections on this week's #NightshiftEditor sessions:

1) Suggestions to limit potential misunderstandings when presenting multiple effect estimates
https://academic.oup.com/aje/article/177/4/292/147738
#Table2Fallacy

2) From the instant classic "on the 12th day of Christmas, a statistician sent to me":
(i) "Do not dichotomise continuous variables"
(ii) "Carefully account for missing data" #STROBE
https://www.bmj.com/content/379/bmj-2022-072883

3) We all can work on asking better research questions
https://rdcu.be/diEEb

#HRQL #ScienceEditing

The Table 2 Fallacy: Presenting and Interpreting Confounder and Modifier Coefficients

Abstract. It is common to present multiple adjusted effect estimates from a single model in a single table. For example, a table might show odds ratios for

OUP Academic

Regardless of COVID, it seems that causal inference methods are finally entering the mainsteam.

Use of #DAGs & awareness of #ColliderBias and the #Table2Fallacy are skyrocketting! Even a general medical journal (JAMA) has now produced primers on these issues

But we are still desparately short of advice and guidance on how best to use causal inference methods for applied research; we need more funding for meta-science and methods translation!

#EpiVerse

https://jamanetwork.com/journals/jama/fullarticle/2790247

Collider Bias

This JAMA Guide to Statistics and Methods describes collider bias, illustrates examples in directed acyclic graphs, and explains how it can threaten the internal validity of a study and the accurate estimation of causal relationships in randomized clinical trials and observational studies.

@[email protected] @[email protected] @[email protected] Abs 2274 cont'd

In the MVA, these factors were a/w disease flare:
>mod/high disease activity
>RTX use
>med holding

🤔Always consider the possibility of #Table2Fallacy & when/how data were collected

#ACR22

@[email protected] @[email protected] Abs 2202 cont'd

Acute care use was higher among those with Black race, who resided in the South, with dual Medicare/Medicaid insurance
🤔Need to consider whether #Table2Fallacy is playing a part in the interpretation of these MVA results

#ACR22

The Table 2 Fallacy: Presenting and Interpreting Confounder and Modifier Coefficients

Abstract. It is common to present multiple adjusted effect estimates from a single model in a single table. For example, a table might show odds ratios for

OUP Academic

@[email protected] @[email protected] #Table2Fallacy

The effect estimates for the blue (exposure of interest) are interpretable ✅

The effect estimates for the red (confounders that were also adjusted for) may not be interpretable 🛑

#ACR22

@[email protected] @[email protected] Finally, #Table2Fallacy

Table 2 is often used to show the adjusted results of the exposure

Variable types are highlighted in this Table 1:
🔹Exposure of interest in blue
🍎Outcomes in red
🍏Confounders (that were adjusted for) in green

#ACR22 https://t.co/Gz7v0Fdu5w

Rheum Cat on Twitter

“@MikeLaValley8 @BU_BMC_Rheum Finally, #Table2Fallacy Table 2 is often used to show the adjusted results of the exposure Variable types are highlighted in this Table 1: 🔹Exposure of interest in blue 🍎Outcomes in red 🍏Confounders (that were adjusted for) in green #ACR22”

Twitter