PLOS Biology#SymmetryBreaking in sea urchins. Early D/V axis in #SeaUrchin embryo depends on inhibin-like TGF-β Panda, but how? Study shows that Panda sequesters TGF-β type II receptor ACVRII, promoting (rather than antagonizing) Nodal signaling #PLOSBiology https://plos.io/4cDs7On
Maternal TGF-β ligand Panda breaks the radial symmetry of the sea urchin embryo by antagonizing the Nodal type II receptor ACVRII
The establishment of the dorsal-ventral axis during early development of the sea urchin embryo is dependent on the antagonistic activity of the inhibin-like TFG-β Panda, which opposes Nodal signaling through an unknown mechanism. This study shows that, in Paracentrotus lividus, Panda sequesters the TGF-β type II receptor ACVRII promoting, rather than antagonizing, Nodal signaling.
Phys.org
Jim Donegan 🎵 ✅