@nmrchat Published last week in
Science SIgnaling: https://www.science.org/doi/10.1126/scisignal.add0509
Proud to cooperate in this multi-disciplinary, multi-national🇳🇴🇮🇹🇦🇹🇨🇿research of @unioslo,
#CERM_cirmmp, #JKULinz, and Univ of South Bohemia as PI for #NMR studies on #calcium channel protein #STIM1 mutations. Deletion of one amino acid reverses the pathological effect of a STIM1 mutation in vitro and in vivo #calciumsignaling

Moderate cold is sensed by #TRPM8 channels, but what about extreme cold?
Peter McNaughton, Tamara Buijs et al at Kings College London identify a #STIM1-#ORAI-mediated mechanism in sympathetic #neurons that may prevent #frostbite through cold‐induced#vasodilation
https://www.embopress.org/doi/10.15252/embj.2022111348