Haojia WuProx-seq for simultaneous measurement of proteins, protein complexes and mRNAs in thousands of single cells! With this multi-modal profiling technique, the authors were able to directly measure the protein complexes on naïve CD8+ T cells and protein interactions during TLR4 activation in macrophages. #singlecell #multimodal #newtech #CITEseq #REAPseq
https://www.nature.com/articles/s41592-022-01684-z
https://www.nature.com/articles/s41592-022-01684-z
Quantification of extracellular proteins, protein complexes and mRNAs in single cells by proximity sequencing - Nature Methods
This work presents Prox-seq that couples sequencing and proximity ligation assay to simultaneously measure extracellular proteins, protein–protein interactions and mRNA in single cells.