CellBioNewsMay 8, 2024

Researchers study the intricacies of #homologous #recombination and abnormal #chromosome_bridges.

#DNA_repair #RAD51 #FIGNL1

https://phys.org/news/2024-05-intricacies-homologous-recombination-abnormal-chromosome.html

Researchers study the intricacies of homologous recombination and abnormal chromosome bridges

Keeping the genetic information stored in genomic DNA intact during the cell division cycle is crucial for almost all lifeforms. Extensive DNA damage invariably causes various adverse genomic rearrangements, which can lead to cell death in the best cases and to the occurrence of diseases like cancer in the worst cases.

Phys.org
CellBioNewsMar 5, 2024

Newly discovered #protein prevents #DNA #triplication.

#mitosis #RAD51 #ORI

https://phys.org/news/2024-03-newly-protein-dna-triplication.html

Newly discovered protein prevents DNA triplication

Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent. This means that, millions of times a day, a biochemical wonder takes place in the body: the copying of the DNA molecule. It is a high-precision job carried out by specific proteins and includes systems to protect against potential errors that could lead to diseases such as cancer.

Phys.org
The EMBO JournalSep 5, 2023
Is loss of #RAD51 #recombinase function pro-tumorigenic similar to other homologous recombination factor mutations?
New mouse model reveals a premature aging, but anti-#tumorigenic effect of dominant-negative SMRAD51 expression!
Gabriel Matos-Rodrigues, Bernard Lopez, Emmanuelle Martini and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022110844