Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications [2026]
https://pmc.ncbi.nlm.nih.gov/articles/PMC12855666
"Polydeoxyribonucleotide (PDRN) is a DNA-derived compound primarily extracted from the sperm of Oncorhynchus mykiss (Salmon Trout) or Oncorhynchus keta (Chum Salmon), consisting of polymeric chains of deoxyribonucleotides with molecular weights ranging from 50 to 1500 kDa [1]. From a single salmon or trout, approximately 5–10 mL of milt (sperm) can be obtained to yield these low-molecular-weight DNA fragments, including PDRN and other polynucleotides.2 In practical terms, PDRN is essentially a mixture of DNA fragments."
"PDRN’s therapeutic effects in tissue regeneration are primarily achieved through two mechanisms: (1) the salvage pathway, and (2) activation of adenosine A2A receptors."





