RNA 3′end tailing safeguards cells against products of pervasive transcription termination - Nature Communications

Pervasive transcription generates numerous unadenylated RNAs, usually degraded by the NEXT/nuclear exosome pathway. Here, the authors show that, upon NEXT inactivation, these RNAs are removed by compensatory RNA decay pathways relying on RNA 3′end A- or U-tailing.