PLOS BiologyApr 15, 2025
ER-resident IRE1 plays a role in #cancer development via enzymatic activation of XPB1 TFs and regulated #RNAdecay. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote #CellCycle progression & tumor growth @PLOSBiology https://plos.io/3EaNFX4
A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

ER-resident IRE1 is known to play a role in cancer development through its enzymatic activation of XPB1 transcription factors and of regulated RNA decay. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote cell cycle progression and tumor growth.

Amelia Cervera 🧬Dec 19, 2024

RNA 3′end tailing safeguards cells against products of pervasive transcription termination.

#RNA #RNAdecay #RNAexosome #NEXT #PAXT

https://www.nature.com/articles/s41467-024-54834-6

RNA 3′end tailing safeguards cells against products of pervasive transcription termination - Nature Communications

Pervasive transcription generates numerous unadenylated RNAs, usually degraded by the NEXT/nuclear exosome pathway. Here, the authors show that, upon NEXT inactivation, these RNAs are removed by compensatory RNA decay pathways relying on RNA 3′end A- or U-tailing.

Nature
Amelia Cervera 🧬Nov 26, 2024

Improved RNA stability estimation through Bayesian modeling reveals most Salmonella transcripts have subminute half-lives.

#RNAstability #Salmonella #RBPs #RNAdecay

https://www.pnas.org/doi/epub/10.1073/pnas.2308814121