ScienceOpen🆕 'Potential Roles of the Nasal Microbiome in Pathogen Exposures in Dairy Workers' - a #Zoonoses published article on #ScienceOpen 📄🔓 https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2025-0012
#NasalMicrobiome #OneHealth #OccupationalHealth #AgriculturalHealth
Potential Roles of the Nasal Microbiome in Pathogen Exposures in Dairy Workers
<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d16921885e193"> <!-- named anchor --> </a> <h5 class="section-title" id="d16921885e194">Objective:</h5> <p dir="auto" id="d16921885e196">Livestock workers are exposed to bioaerosols comprising pathogens including influenza D virus (IDV), influenza A (IAV), and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), all of which can colonize the upper airways (e.g., anterior nares) and pose public health risks. The role of the nasal microbiome in occupational exposure is not well understood. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d16921885e201"> <!-- named anchor --> </a> <h5 class="section-title" id="d16921885e202">Methods:</h5> <p dir="auto" id="d16921885e204">Here, we characterized the nasal microbiomes of US dairy workers to investigate the microbiome’s effects on pathogen carriage. We collected 237 lavages from 31 dairy workers to determine the presence of influenzas A, C, and D; methicillin-susceptible <i>Staphylococcus aureus</i> (MSSA); and MRSA. Nasal lavages were analyzed via PCR to quantify workers’ nasal microbiomes, and differences in microbiome characteristics were analyzed according to pathogen presence. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d16921885e209"> <!-- named anchor --> </a> <h5 class="section-title" id="d16921885e210">Results:</h5> <p dir="auto" id="d16921885e212">Overall, 32.1% of lavages tested positive for MSSA, 11.4% tested positive for MRSA, 17.3% tested positive for IDV, 2.5% tested positive for IAV, and 1.3% tested positive for ICV. Nasal samples positive for IAV and those positive for MSSA clustered separately with robust Aitchison PCA, but no significant differences in alpha diversity were observed. Differential abundance analysis revealed significant differences in genera among lavages testing positive for MRSA, MSSA, IDV, and IAV (e.g., <i>Staphylococcus</i>, <i>Streptococcus</i>, and <i>Bacillus</i>). </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d16921885e223"> <!-- named anchor --> </a> <h5 class="section-title" id="d16921885e224">Conclusions:</h5> <p dir="auto" id="d16921885e226">Future work is needed to ascertain whether the microbiome might protect against pathogen exposures among livestock workers. </p> </div>
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