PLOS BiologyScreen in #Celegans yields potential targets to delay motor #aging, including the PI3K VPS-34. VPS-34 inhibition improves #neurotransmission & muscle integrity via increased PI(3)P-PI-PI(4)P conversion, improving #MotorAging in worms & mice #PLOSBiology https://plos.io/3XNjhHn
Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span
A genome-wide screen in the nematode Caenorhabditis elegans reveals potential targets to delay motor aging, including the phosphatidylinositol 3-kinase VPS-34. Genetic and pharmacological partial inhibition of VPS-34 improves neurotransmission and muscle integrity through increased PI(3)P-PI-PI(4)P conversion, ameliorating motor aging in both worms and mice.