Our
#MidWeekMovie shows the collective migration of a dorsal marginal zone explant from Tien Comlekoglu, Douglas DeSimone and colleagues. In their
@BiologyOpen paper, they use computational modelling to interrogate the mechanics of collective cell migration.
https://journals.biologists.com/bio/article/13/8/bio060615/361690/Modeling-the-roles-of-cohesotaxis-cellIt’s time for our
#MidweekMovie! This week we’re tracking EB1 comets with Sarah Attrill, Liam Dolan & colleagues. They find that microtubules and actin filaments direct nuclear movement during the polarisation of Marchantia spore cells.
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@Dev_journal:
https://journals.biologists.com/dev/article/151/20/dev202823/361226/Microtubules-and-actin-filaments-direct-nuclear#DevSIDiversityOur
#MidweekMovie shows confined migration of MDA-MB-231 cells, a metastatic breast cancer cell line. Check out the
@J_Cell_Sci article from Jeremy Keys & Jan Lammerding to learn more about how these cells move through constrictions.
https://journals.biologists.com/jcs/article/137/12/jcs260623/358079/Rear-cortex-contraction-aids-in-nuclear-transitI swallowed a bug
That should say what this evening’s movie might be😀
#moviequote #midweekmovie #serenity
Our
#MidweekMovie shows a long process being emitted from a Müller cell (turquoise) following engagement with a microglia cell (red) from Michael Morales, Anna Findley and Diana Mitchell.
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@Dev_journal:
https://journals.biologists.com/dev/article/151/1/dev202407/340240/Intercellular-contact-and-cargo-transfer-between#OpenAccess #ReadandPublish
Intercellular contact and cargo transfer between Müller glia and to microglia precede apoptotic cell clearance in the developing retina
Summary: Real-time imaging of developing zebrafish retinas reveals intercellular exchanges between Müller glial cells and with microglia during the clearance of apoptotic cells.
Our
#MidweekMovie is from Manal Hosawi, Salah Elias and colleagues. They identify a plasma membrane-mediated mechanism that maintains epithelial identity for correct polarised cell divisions.
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@J_Cell_Sci:
https://journals.biologists.com/jcs/article/137/5/jcs261701/335719/Interplay-between-the-plasma-membrane-and-cell# JCSCellandTissuePolarity
Interplay between the plasma membrane and cell–cell adhesion maintains epithelial identity for correct polarised cell divisions
Summary: In this study, we identify a plasma membrane-mediated mechanism that maintains epithelial cell identity to ensure correct execution of polarised cell divisions, genome maintenance and safeguard tissue integrity.
Our
#MidweekMovie shows BFA-induced Golgi disassembly in vimentin KO MEFs from Teresa Vitali, Martin Lowe and colleagues. They find that vimentin intermediate filaments provide structural support in the Golgi.
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@J_Cell_Sci https://journals.biologists.com/jcs/article/136/20/jcs260577/333533/Vimentin-intermediate-filaments-provide-structural
Vimentin intermediate filaments provide structural stability to the mammalian Golgi complex
Summary: Vimentin intermediate filaments associate with the trans-Golgi network protein GORAB and provide structural stability to the Golgi complex in mammalian cells.
Our
#MidweekMovie is a 24-hr time-lapse recording of dl1 axons in cultured intact chicken spinal cord from Nikole Zuñiga, Esther Stoeckli and colleagues. They find that Cables1 is necessary for correct navigation of post-crossing commissural axons.
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@Dev_journal:
https://journals.biologists.com/dev/article/150/19/dev201671/330799/Cables1-links-Slit-Robo-and-Wnt-Frizzled-signaling
Cables1 links Slit/Robo and Wnt/Frizzled signaling in commissural axon guidance
Summary: Commissural axons leave the floor plate and turn rostral by a smooth transition from Robo to Wnt signaling. Cables1 links these pathways by transferring Abl kinase from Robo to β-catenin.
In our
#MidweekMovie, we highlight migration and morphogenesis of visceral muscles in the forming Drosophila midgut from Manfred Frasch and colleagues. They identify Tey as crucial regulator for the arrangement of longitudinal gut muscles.
@Dev_journal:
https://journals.biologists.com/dev/article/150/18/dev201457/328427/The-RNF220-domain-nuclear-factor-Teyrha-Meyrha-Tey
The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila
Summary: Examination of the migration and morphogenesis of Drosophila visceral muscle precursors reveals how these multinucleated precursors form the stereotypic arrangement of longitudinal gut muscles and identifies Tey as a crucial regulator of this process.
Our #MidWeekMovie shows collective migration of Drosophila follicular epithelial cells. Audrey Miller Williams & Sally Horne-Badovinac discover that trailing edge-enriched Fat2 localises Lar and Sema5c, in trans, to the leading edge to coordinate collective cell migration.
📖 @J_Cell_Sci: https://journals.biologists.com/jcs/article/137/5/jcs261173/328137/Fat2-polarizes-Lar-and-Sema5c-to-coordinate-the
#cellbiology #microscopy
Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells
Summary: In the migrating follicular epithelium of Drosophila, trailing edge-enriched Fat2 concentrates Lar and Sema5c in trans at leading edges; they then act in parallel to promote collective migration.
FocalPlane
Tim ☑️ 🔭🌃📷🪨🚴🌳