Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174

Lysophosphatidylserine (LysoPS) is a lipid signalling molecule implicated in a range of processes related to the immune system. This structural study reveals the mechanism of LysoPS recognition by two G protein-coupled receptors, GPR34 and GPR174, offering insights into lysophospholipid signaling and presenting opportunities for drug discovery.