Jamaica's leptospirosis cases increase; deaths jump to 12 - CNW Network

Jamaica continues to grapple with the leptospirosis outbreak, with the Ministry of Health reporting an increase in confirmed cases and deaths. 

Người phụ nữ nguy kịch vì xoắn khuẩn có trong nước ngập

Người phụ nữ sốt cao đột ngột, kiệt sức được đi cấp cứu nhưng nhanh chóng rơi vào nguy kịch, suy đa tạng.

Leptospirosis Complicated by Secondary Hemophagocytic Lymphohistiocytosis in a Child: A Rare Association

<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d89213e99"> <!-- named anchor --> </a> <h5 class="section-title" id="d89213e100">Aims and background</h5> <p dir="auto" id="d89213e102">Leptospirosis is caused by spirochetes of the genus <i>Leptospira</i>. In most patients, it is a very mild illness. However, some patients develop complications due to the involvement of multiple organ systems. Hemophagocytic lymphohistiocytosis (HLH) is characterized by prolonged fever, hepatosplenomegaly and cytopenias, hyperferritinemia and hypertriglyceridemia, hypofibrinogenemia, and hemophagocytosis in lymphoreticular system. It may occur primarily as a result of some genetic predisposition or secondarily associated with certain infections, autoimmune, and malignant conditions [secondary hemophagocytic lymphohistiocytosis (sHLH)]. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d89213e107"> <!-- named anchor --> </a> <h5 class="section-title" id="d89213e108">Case description</h5> <p dir="auto" id="d89213e110">We report a 9-year-old girl with secondary HLH associated with Leptospira infection treated successfully with appropriate antibiotics and intravenous immunoglobulin. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d89213e112"> <!-- named anchor --> </a> <h5 class="section-title" id="d89213e113">Conclusion</h5> <p dir="auto" id="d89213e115">Progressive cytopenia associated with deteriorating clinical condition with recurrence or nonabatement of fever should lead the clinician to suspect sHLH. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d89213e117"> <!-- named anchor --> </a> <h5 class="section-title" id="d89213e118">Clinical significance</h5> <p dir="auto" id="d89213e120">Leptospirosis precipitating HLH has rarely been reported.</p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d89213e122"> <!-- named anchor --> </a> <h5 class="section-title" id="d89213e123">How to cite this article</h5> <p dir="auto" id="d89213e125">Nandi M, Bera S. Leptospirosis Complicated by Secondary Hemophagocytic Lymphohistiocytosis in a Child: A Rare Association. Pediatr Inf Dis 2025;7(1):27–29. </p> </div>

Successful utilization of plasma exchange and corticosteroids in the management of thrombotic microangiopathy and acute respiratory distress syndrome secondary to leptospirosis-a case report

<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863344e181"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863344e182">Background:</h5> <p dir="auto" id="d2863344e184">Leptospirosis, a zoonotic infection caused by <i>Leptospira</i> bacteria, presents with symptoms ranging from mild flu-like signs to severe multiorgan failure. A rare but serious complication of leptospirosis is thrombotic microangiopathy (TMA). This case report discusses the treatment of a 52-year-old female with leptospirosis complicated by TMA, highlighting the effectiveness of plasma exchange and corticosteroids in her recovery. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863344e189"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863344e190">Case Presentation:</h5> <p dir="auto" id="d2863344e192">A 52-year-old female presented with a five-day history of fever and progressive shortness of breath. Upon admission, she had tachypnoea, a partial pressure of oxygen in arterial blood (PaO2) to the fraction of inspiratory oxygen concentration (FiO2) ratio of 61, and bilateral lung infiltrates, requiring invasive mechanical ventilation and prone positioning. Laboratory tests revealed anemia, thrombocytopenia, schistocytes, and elevated lactate dehydrogenase, suggesting TMA. The patient also showed elevated liver enzymes and signs of a potential diagnosis of thrombotic thrombocytopenic purpura, though serological tests for tropical infections, including leptospirosis, were initially negative. The patient was treated with plasma exchange and corticosteroids, leading to improvements in her hematological parameters and acute respiratory distress syndrome (ARDS). However, she developed unexplained blood pressure and heart rate fluctuations, and electroencephalogram confirmed focal seizures, which were treated with levetiracetam and propofol. Subsequent serological testing confirmed leptospirosis with positive Immunoglobulin M antibodies and Leptospira polymerase chain reaction testing. The patient was treated with doxycycline and ceftriaxone, resulting in significant improvement, successful extubation, and eventual discharge. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863344e194"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863344e195">Conclusion:</h5> <p dir="auto" id="d2863344e197">This case highlights the challenges of managing leptospirosis complicated by TMA and severe ARDS. Plasma exchange and corticosteroids were essential in the patient’s recovery. The initial delay in diagnosis due to negative serological tests underscores the importance of maintaining a high index of suspicion for leptospirosis in severe tropical illness cases with TMA. The patient’s positive response to treatment, including resolution of seizures and hemodynamic instability, demonstrates the value of prompt and targeted interventions. The case emphasizes the need for a multidisciplinary approach in managing complex leptospirosis cases with severe complications. </p> </div>

Salud integral: trabajando por el bienestar de los animales y las personas

Salud integral: trabajando por el bienestar de los animales y las personas Tendencias - El Mundo CR

Servicio de noticias en salud Al Día – Los niños están muriendo»: la leptospirosis causa estragos entre indígenas de Ecuador

Radio Antisana Media Online

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