Matt HodgkinsonDon't get health advice from ChatGPT.
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ScienceOpenπ The Karger: #Ophthalmology publications address the management of #RetinalDiseases using new imaging methods and therapy #CaseReports, as well as surgical treatment of, for example, #OphthalmicCancer. π¬ποΈ
π https://www.scienceopen.com/collection/Karger_Ophthalmology
Karger: Ophthalmology
<p>Ophthalmologists will find a variety of highly relevant content in ophthalmology. Karger publications address the management of retinal diseases using new imaging methods or case reports in therapy as well as surgical treatment of, for example, ophthalmic cancer</p>
ππ©Ί 'Successful utilization of plasma exchange and corticosteroids in the management of thrombotic microangiopathy and acute respiratory distress syndrome secondary to leptospirosis-a case report' - published in the European Journal of Medical #CaseReports (EJMCR) on #ScienceOpen:
π Discover STM Publishing Ltd, Ireland: https://www.scienceopen.com/hosted-document?doi=10.24911/ejmcr.173-1724599359
#Leptospirosis #InfectiousDiseases #CriticalCare #PlasmaExchange #TropicalMedicine
Successful utilization of plasma exchange and corticosteroids in the management of thrombotic microangiopathy and acute respiratory distress syndrome secondary to leptospirosis-a case report
<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863344e181"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863344e182">Background:</h5> <p dir="auto" id="d2863344e184">Leptospirosis, a zoonotic infection caused by <i>Leptospira</i> bacteria, presents with symptoms ranging from mild flu-like signs to severe multiorgan failure. A rare but serious complication of leptospirosis is thrombotic microangiopathy (TMA). This case report discusses the treatment of a 52-year-old female with leptospirosis complicated by TMA, highlighting the effectiveness of plasma exchange and corticosteroids in her recovery. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863344e189"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863344e190">Case Presentation:</h5> <p dir="auto" id="d2863344e192">A 52-year-old female presented with a five-day history of fever and progressive shortness of breath. Upon admission, she had tachypnoea, a partial pressure of oxygen in arterial blood (PaO2) to the fraction of inspiratory oxygen concentration (FiO2) ratio of 61, and bilateral lung infiltrates, requiring invasive mechanical ventilation and prone positioning. Laboratory tests revealed anemia, thrombocytopenia, schistocytes, and elevated lactate dehydrogenase, suggesting TMA. The patient also showed elevated liver enzymes and signs of a potential diagnosis of thrombotic thrombocytopenic purpura, though serological tests for tropical infections, including leptospirosis, were initially negative. The patient was treated with plasma exchange and corticosteroids, leading to improvements in her hematological parameters and acute respiratory distress syndrome (ARDS). However, she developed unexplained blood pressure and heart rate fluctuations, and electroencephalogram confirmed focal seizures, which were treated with levetiracetam and propofol. Subsequent serological testing confirmed leptospirosis with positive Immunoglobulin M antibodies and Leptospira polymerase chain reaction testing. The patient was treated with doxycycline and ceftriaxone, resulting in significant improvement, successful extubation, and eventual discharge. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863344e194"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863344e195">Conclusion:</h5> <p dir="auto" id="d2863344e197">This case highlights the challenges of managing leptospirosis complicated by TMA and severe ARDS. Plasma exchange and corticosteroids were essential in the patientβs recovery. The initial delay in diagnosis due to negative serological tests underscores the importance of maintaining a high index of suspicion for leptospirosis in severe tropical illness cases with TMA. The patientβs positive response to treatment, including resolution of seizures and hemodynamic instability, demonstrates the value of prompt and targeted interventions. The case emphasizes the need for a multidisciplinary approach in managing complex leptospirosis cases with severe complications. </p> </div>
ππ©Ί 'Pulmonary mucormycosis after heart transplantation: an uncommon case report' - published in the European Journal of Medical #CaseReports (EJMCR) on #ScienceOpen:
π Discover STM Publishing Ltd, Ireland: https://www.scienceopen.com/hosted-document?doi=10.24911/ejmcr.173-1728576804
#InfectiousDiseases #HeartTransplant #PulmonaryMCR #MedicalMycology
Pulmonary mucormycosis after heart transplantation: an uncommon case report
<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863153e159"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863153e160">Background:</h5> <p dir="auto" id="d2863153e162">Mucormycosis (MCR) is an uncommon but frequently deadly fungal infection that typically affects individuals with weakened immune systems. Pulmonary MCR, in particular, is most frequently observed in patients who have undergone stem cell or solid organ transplants. The incidence of MCR in solid organ transplant recipients is reported to be 0.07% within the first year. In almost 40% of these transplant patients, including the case we examined, the infection is diagnosed within the first 6 months after the transplant. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863153e164"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863153e165">Case Presentation:</h5> <p dir="auto" id="d2863153e167">We report a rare case of a 67-year-old man who developed pulmonary MCR within 6 months after undergoing a heart transplant. A bronchoscopy was conducted, and Reverse transcription polymerase chain reaction along with cultures of the broncho-alveolar samples tested positive for Mucorales. After consulting with experts from thoracic and vascular surgery, cardiology, pulmonology, and microbiology, and adhering to the expert guidelines, a semi-urgent source control procedure was recommended. This involved performing a thoracoscopic exploration of the right pleura, which was subsequently converted to a lateral thoracotomy, culminating in the resection of the right lower lobe. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d2863153e169"> <!-- named anchor --> </a> <h5 class="section-title" id="d2863153e170">Conclusion:</h5> <p dir="auto" id="d2863153e172">Invasive MCR is a rare but serious fungal infection with a high risk of illness and death, particularly in people with underlying health issues or weakened immune systems. The clinical and imaging manifestations can vary among patients based on their immune status and how they contracted the infection. Despite these variations, it is vital to maintain a high level of suspicion for MCR, as early diagnosis and the rapid initiation of surgical and antifungal treatments are critical for improving survival chances. </p> </div>
ππ©Ί The ππΆπ³π°π±π¦π’π― ππ°πΆπ³π―π’π π°π§ ππ¦π₯πͺπ€π’π ππ’π΄π¦ ππ¦π±π°π³π΅π΄ (EJMCR) is a peer-reviewed, #OpenAccess journal dedicated to the publication of high-quality #CaseReports across the field of #Medicine.
Discover STM Publishing Ltd, Ireland: π https://www.scienceopen.com/collection/DiscoverSTMPublisher_EJMCR