''As
#oseltamivir is the most widely used therapeutic and prophylactic against IAV, the continued
#circulation of viruses harboring NA-
#H275Y may necessitate a re-evaluation of
#influenza #treatment #strategies in
#Canada.''
Whole-Genome #Analysis of #Influenza #H1N1pdm09 Viruses Isolated from ILI #Outpatients in #Myanmar & CA #Oseltamivir-Resistant Strains Present from 2015 to 2019 https://pubmed.ncbi.nlm.nih.gov/39205274/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=10ykRO9og5pGdo51l9DEPEpOJ3DVFIn__QK2QPM3dci1C1dEYq&fc=None&ff=20240831103754&v=2.18.0.post9+e462414
3 viruses possessed the #H275Y substitution in #neuraminidase protein, appearing to be community-acquired without prior administration of neuraminidase inhibitors. These viruses exhibited highly reduced susceptibility to #oseltamivir and #peramivir.
Whole-Genome Analysis of the Influenza A(H1N1)pdm09 Viruses Isolated from Influenza-like Illness Outpatients in Myanmar and Community-Acquired Oseltamivir-Resistant Strains Present from 2015 to 2019 - PubMed
In this study, we describe the genetic characteristics of influenza A(H1N1)pdm09 strains detected in Myanmar from 2015 to 2019. Whole genomes from 60 A(H1N1)pdm09 virus isolates were amplified using real-time polymerase chain reaction and successfully sequenced using the Illumina iSeq100 platforms. …
Whole- #Genome #Analysis of #Influenza #H1N1pdm09 Viruses Isolated from #ILI #Outpatients in #Myanmar & Community-Acquired #Oseltamivir - #Resistant Strains Present from 2015 to 2019 https://www.mdpi.com/1999-4915/16/8/1300
1 virus intra-subtype reassortment, collected in the '15 season. 3 viruses possessed #H275Y substitution in NA protein, appearing to be CA without prior administration of neuraminidase #inhibitors. These viruses exhibited highly reduced susceptibility to #oseltamivir & #peramivir.
Whole-Genome Analysis of the Influenza A(H1N1)pdm09 Viruses Isolated from Influenza-like Illness Outpatients in Myanmar and Community-Acquired Oseltamivir-Resistant Strains Present from 2015 to 2019
In this study, we describe the genetic characteristics of influenza A(H1N1)pdm09 strains detected in Myanmar from 2015 to 2019. Whole genomes from 60 A(H1N1)pdm09 virus isolates were amplified using real-time polymerase chain reaction and successfully sequenced using the Illumina iSeq100 platforms. Eight individual phylogenetic trees were retrieved for each segment along with those of the World Health Organization (WHO)-recommended Southern Hemisphere vaccine strains for the respective years. A(H1N1)pdm09 viruses from 2015 were found to belong to clade 6B, those from 2016 to 6B.1, 2017 to 6B.1A, and 2019 to 6B.1A.5a, and were genetically distinct from the Southern Hemisphere vaccine strains for the respective seasons, A/California/7/2009 and A/Michigan/45/2015. We observed one virus with intra-subtype reassortment, collected in the 2015 season. Importantly, three viruses possessed the H275Y substitution in the neuraminidase protein, appearing to be community-acquired without the prior administration of neuraminidase inhibitors. These viruses exhibited highly reduced susceptibility to oseltamivir and peramivir. This study demonstrates the importance of monitoring genetic variations in influenza viruses that will contribute to the selection of global influenza vaccines.
Giuseppe Michieli