"In this report, we summarize the results obtained over the past decade."
Which funding agency, which institution could sport such time ranges? #HHMI of course.
"A split-GAL4 driver line resource for Drosophila CNS cell types", Meissner et al. 2024
https://www.biorxiv.org/content/10.1101/2024.01.09.574419v3.full
@kofanchen @flypapers @ycchen_tw
"we use existing developmental single-cell RNA sequencing (scRNAseq) datasets to select gene pairs for split-GAL4 and provide a highly efficient and predictive pipeline (scMarco) to generate cell-type-specific split-GAL4 lines at any time during development, based on the native gene regulatory elements."
Would love to see this in action, particularly in larvae of course.
Single neuron images of Drosophila driver lines reveal neuron shape and are searchable, enabling comparisons to electron microscopy and prediction of intersectional neuron targeting strategies.
Albert Cardona
daniodanionella