Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan | Nature Aging

Mitochondrial dysfunction plays a central role in aging but the exact biological causes are still being determined. Here, we show that optogenetically increasing mitochondrial membrane potential during adulthood using a light-activated proton pump improves age-associated phenotypes and extends lifespan in Caenorhabditis elegans. Our findings provide direct causal evidence that rescuing the age-related decline in mitochondrial membrane potential is sufficient to slow the rate of aging and extend healthspan and lifespan. Using light to optogenetically power mitochondria, this study shows that opposing the age-related decline in mitochondrial membrane potential leads to increased healthspan and lifespan in Caenorhabditis elegans. This result points to mitochondrial charge as a fundamental regulator of biological aging.