Regular exercise induces the liver to produce betain, a metabolite that blocks inflammation and has potential anti-aging effects. Dosing mice with betain results in many of the same effects as exercise on metabolism, inflammation, and cognitive function.

Summary: https://www.sciencedaily.com/releases/2025/11/251113071620.htm

Original paper (not open access): https://www.cell.com/cell/abstract/S0092-8674(25)00635-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286742500635X%3Fshowall%3Dtrue

#Science #Health #Exercise #Aging #ExerciseMimetic #Betain

Scientists find a molecule that mimics exercise and slows aging

Exercise appears to spark a whole-body anti-aging cascade, and scientists have now mapped out how it happens—and how a simple oral compound can mimic it. By following volunteers through rest, intense workouts, and endurance training, researchers found that the kidneys act as the hidden command center, flooding the body with a metabolite called betaine that restores balance, rejuvenates immune cells, and cools inflammation. Even more striking, giving betaine on its own reproduced many benefits of long-term training, from sharper cognition to calmer inflammation.

ScienceDaily