Have lots of threads to do but watching #ESICM latest research propafenone vs amiodarone for AF in sepsis - seems to be faster, as safe, and with les breakthrough AF, no higher harm signal. Amio better for dilated LA, propa better for non dilated. Previous non RCTs suggest twelve month mortality better in propa #criticalcare #LIVES2023

Neutrophils can harbour pathogens up to six days - indeed neutropaenic patients may survive staph infections better than the normal one #ESICM

Pulmonary infection is protective in reprogramming immune response to a pneumonia versus an antecedent non pulmonary infection #ESICM likewise e.coli infections prime against pseudomonas

So oxygen delivery even in tissues is not a problem in sepsis, they won’t increase oxygen consumption even when it’s there (and it is) #ESICM #LIVES2023

Don’t stop steroids too early in refractory shock and not before three days as rebound inflammation. Continue for seven days #ESICM

Mineralocorticoid may be more important than GC receptor in steroid responsiveness of alpha receptor sensitivity #ESICM