Hot Topics session always closes @ESICM -

Moderated by Derek Angus JAMA , Darren Taichman NEJM, & #ESICM President @ElieAzoulay5

#LIVES2023

Can’t wait for the new one which is about to be released at #LIVES2023 #ESICM

(Even if I’ll have to update my talk)

Have lots of threads to do but watching #ESICM latest research propafenone vs amiodarone for AF in sepsis - seems to be faster, as safe, and with les breakthrough AF, no higher harm signal. Amio better for dilated LA, propa better for non dilated. Previous non RCTs suggest twelve month mortality better in propa #criticalcare #LIVES2023
@gpollara @jopo_dr Thanks for posting from #ESICM! Don’t suppose you remember a reference for this?
Neutrophils can harbour pathogens up to six days - indeed neutropaenic patients may survive staph infections better than the normal one #ESICM
Pulmonary infection is protective in reprogramming immune response to a pneumonia versus an antecedent non pulmonary infection #ESICM likewise e.coli infections prime against pseudomonas
So oxygen delivery even in tissues is not a problem in sepsis, they won’t increase oxygen consumption even when it’s there (and it is) #ESICM #LIVES2023
This means people are adding fludrocortisone to hydrocortisone in refractory shock #ESICM #LIVES2023
Don’t stop steroids too early in refractory shock and not before three days as rebound inflammation. Continue for seven days #ESICM
Mineralocorticoid may be more important than GC receptor in steroid responsiveness of alpha receptor sensitivity #ESICM