Hao YinNov 9, 2022

#EndothelialCell Mst1 KO->
⏫EC inflammation by #OscillatoryShearStress 0.5±4 dyn/cm2 1 Hz
⏫🐭#Atherosclerosis

Independent of #YAP (?TAZ🧐)

Mst1 phosphorylates #Connexin43->⏬Hemichannel activity, not gap junction coupling

Dr. Ding Ai lab Circ Res 2022
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.122.321322

MST1 Suppresses Disturbed Flow Induced Atherosclerosis

Background: Atherosclerosis occurs mainly at arterial branching points exposed to disturbed blood flow. How MST1 (mammalian sterile 20-like kinase 1), the primary kinase in the mechanosensitive Hippo

Circulation Research