Low #OscillatoryShearStress->
β«Osteopontin-CD44 in #EndothelialCell->
β«EndMT->
β«24% of neointimal cells at rat aortocaval junction
A cascade independent of #HyaluronicAcidπ€
Dr. Yung-Hsin Yeh lab Kidney Int 2023
https://www.kidney-international.org/article/S0085-2538(23)00011-X/fulltext
#EndothelialCell Mst1 KO->
β«EC inflammation by #OscillatoryShearStress 0.5Β±4 dyn/cm2 1 Hz
β«π#Atherosclerosis
Independent of #YAP (?TAZπ§)
Mst1 phosphorylates #Connexin43->β¬Hemichannel activity, not gap junction coupling
Dr. Ding Ai lab Circ Res 2022
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.122.321322
Hao Yin