CellBioNewsScientists uncover mechanism preserving #centromere during #cell_division.
#mitosis #PLK1 #Mis18 #CENP_A #HJURP #phosphorylation_cascade
https://phys.org/news/2024-09-scientists-uncover-mechanism-centromere-cell.html
How #cells accurately assemble complex machinery.
#proteomics #regulation #CENP_A #kinetochore
https://phys.org/news/2024-01-cells-accurately-complex-machinery.html
How cells accurately assemble complex machinery
Proteins are the workhorses of the cell, carrying out functions to keep everything running smoothly. Some proteins work on their own, but in other cases many proteins assemble together to create a complex machine. These proteins are able to do more working cooperatively than they could alone, the same way a single motor is powerful but not nearly as useful as a motor combined with other parts to make a car.
New insights into #centromere structure.
New insights into centromere structure
Researchers led by Osaka University used cryogenic electron microscopy to analyze the atomic structure of the centromeric region of the chromosome, essential for cell division. A protein called CENP-A marks the centromere; the researchers showed that during interphase, CENP-A is bound by a protein called KNL2 to maintain the location of the centromere. During mitosis, KNL2 is replaced by CENP-C, allowing correct formation of the kinetochore complex for cell division.