How do scaffolding proteins regulate the assembly of
#presynaptic #ActiveZones? This study solves the structure of the liprin-α2/RIM1 complex & shows that it is essential for
#synaptic transmission and LLPS-dependent coupling of Ca2+ channels & synaptic vesicles
@PLOSBiology https://plos.io/3Tj5CX7Does neuronal information storage involve nanoscopic structural changes at
#synapses? @olenas_kim &co use nanophysiology & functional EM to reveal structural changes of
#hippocampal #ActiveZones during chemical potentiation @ISTAustria
#PLOSBiology https://plos.io/3V22v7h
Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons
Information storage in neuronal circuits is hypothesized to involve nanoscopic structural changes at synapses, but direct evidence for this is lacking. This study uses nanophysiology and functional electron microscopy to reveal structural changes of hippocampal active zones during chemical potentiation.
PLOS Biology
