Angamaオミクロン株による神経症状が55.4%の患者に確認されました。特に「せん妄」や「脳卒中」などが死亡リスクを増加させることが判明。進化に伴い神経合併症が増加しており、高齢者や既存疾患を持つ方が特に影響を受けやすい状況です。神経系リスクに特化した治療が重要です
（日常語版）
🧠 オミクロン株の進化が脳に与える影響とは？
新しい研究によると、#オミクロン株 に感染した患者の55.4%に神経症状が見られました。これには、「せん妄」や「頭痛」、「脳卒中」などの重大な合併症が含まれ、これらは死亡リスクや入院期間の延長に関連しています。
🔍 何が重要なのか？
1️⃣ 進化するごとに増加する神経症状
オミクロン株の進化（サブバリアントごとに）に伴い、神経合併症の発生率が上昇しています。
2️⃣ 高リスクの対象者
高齢者や持病（糖尿病、心疾患など）を持つ患者が特に影響を受けやすく、注意が必要です。
💡 この発見の意義
オミクロン株が「軽症」と考えられる一方で、神経系への影響が顕著であることがわかりました。特に、高齢者や持病を持つ方は、これらのリスクを考慮した医療対応が重要です。
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
Background/Objectives: The Omicron variant of SARS-CoV-2 is undergoing constant mutation. New strains vary in neuropathogenicity and the neurological spectrum of disease. The aim of this study was to assess the frequency and clinical characteristics of neurological manifestations during the Omicron dominance among hospitalized patients, including the differences between three subsequent periods. Methods: This retrospective single-center study included 426 hospitalized adults with confirmed COVID-19 divided into three periods (O1, O2, and O3) dependent on the dominance of Omicron subvariants in Poland. Demographic and clinical data, in particular neurological manifestations, were collected and compared. Results: The median age of the group was 74, older in subsequent (later) periods. The number of patients with a history of previous SARS-CoV-2 infection or vaccination increased with the duration of the pandemic. The severity of COVID-19 became lower in successive periods. Neurological manifestations were observed in 55.4% of patients, and the most frequent were delirium, headache, myalgia, dizziness, cerebrovascular diseases, and encephalopathy. In subsequent periods of Omicron dominance, a higher frequency of neurological manifestations such as delirium, transient ischemic attack (TIA), and encephalopathy was observed. Headache or myalgia was related to a shorter hospitalization while delirium, cerebrovascular diseases, and ischemic stroke were linked with an increased risk of death. Conclusions: The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations. Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases. The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality.
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