米大規模コホート研究で「5歳未満の14〜15%が感染1年後もロングコロナ様症状」と報告。主な症状は睡眠障害や倦怠感、咳など。一方ドイツ小児専門医は「実際の臨床ではここまで多くない」「症状の定義や親申告の限界に注意が必要」と指摘。年齢・症状別の精密分析が今後の課題
豪州で深刻な登校危機：2019年に「登校率90%以上」だった生徒は73.1%→2024年はわずか59.8%へ激減。4割以上が10日中1日以上欠席。さらに特別支援校の在籍者も2016年比で276%増。単純な“学校拒否”ではなく、身体的・環境的な複合要因への支援と全国統一のデータ整備が急務
WHOが新たな監視下変異株「XFG（Stratus）」を指定。世界で急増し、直近4週間で7.4%→22.7%に。南アジアで特に優勢化。成長速度が高く、NB.1.8.1やLP.8.1など既存変異株より拡大ペースが上回る。スパイク変異で一部免疫逃避も。今後も厳重な監視が必須。
SARS-CoV-2のタンパク質Nsp14は、炎症反応（NF-κB/MAPK経路）を活性化してサイトカイン産生を促し、同時にインターフェロンα/γ受容体を細胞表面から減少させることで抗ウイルス免疫を回避。細胞内因子Tollipと結合し両作用を発揮。重症化や後遺症の新たな分子標的として注目
米国心臓協会が声明発表。コロナ感染は心房細動や徐脈、不整脈、突然死リスクを高め、回復後も自律神経異常（POTSなど）や不整脈の長期リスクが続く。重症でなくても危険度は増加し、再感染で蓄積リスクも。治療や経過観察が重要と警告
コロナ感染で腸内細菌「アッカーマンシア・ムシニフィラ」が増えると、腸で教育された免疫細胞や代謝物が血流を通じて肺へ届き、局所の免疫（記憶T細胞やリンパ組織）を強化＝“腸–肺軸”の働き。マウス実験で肺損傷や体重減少が抑制され、腸内細菌療法が新たな選択肢の可能性
オーストラリアの大規模研究「OUTPOST」が開始。コロナ・インフル・RSV感染後の12歳以上1500人超を1年追跡し、後遺症（倦怠感や脳霧など）の頻度や影響、ケア体制の現状・課題をリアルタイムで調査。参加者には無料検査と謝礼も
インドの研究でコロナ回復者76人の脳MRIを解析、右側の大脳基底核や辺縁系（海馬・扁桃体など）の萎縮、記憶・注意・感情に関わる回路の損傷を確認。重症例ほど顕著で「軽症」でも深部脳の変化。脳疲労や記憶障害、睡眠問題の“根拠”が画像で裏付け
The long-term impact of COVID-19 on the brain is multifaceted, encompassing structural and functional disruptions. A cohesive theory of the underlying mechanisms of the Post-COVID Syndrome (PCS) remains unknown, primarily due to high variability in findings across independent studies. Here, we present a multimodal, cross-sectional MRI analysis of brain morphology (T1-MRI), tissue microstructure (diffusion-MRI), functional connectivity (functional-MRI), and cerebral blood flow (Arterial Spin Labeling MRI) in COVID-Recovered Patients (CRPs, N=76) and Healthy Controls (HCs, N=51). Although the global brain volumes did not differ between the two groups, CRPs showed focal atrophy in the right basal ganglia and limbic structures, along with cortical thinning in paralimbic regions (prefrontal cortex, insula) (p<0.05). Diffusion MRI analysis revealed reduced fractional anisotropy and elevated radial diffusivity in the uncinate fasciculus and cingulum. No differences were observed in resting-state functional connectivity (RSFC) and cerebral blood flow between HCs and CRPs (p>0.05). We further investigated the effect of infection severity by stratifying the CRPs into hospitalized (HP; N = 21) and non-hospitalized (NHP; N = 46) groups. The microstructural damage was linked to infection severity, more pronounced in the HPs (p<0.05). In HPs, RSFC was diminished between components of the default mode network and the insula and caudate as compared to HCs and NHPs (p<0.05). Results suggest COVID-19 is associated with selective structural and functional alterations in basal ganglia–limbic–cortical circuits, with stronger effects in severe cases. Our findings are in line with common prevalent behavioral symptoms such as fatigue, memory impairment, attentional deficits, and insomnia. This study suggests that localized microstructural neuroinflammatory mechanisms contribute to post-COVID neurological symptoms and offers potential imaging biomarkers for targeted therapies and monitoring recovery. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement The work is supported by MeitY (Government of India) under grant 4(16)/2019-ITEA and Cadence Chair Professor fund awarded to Dr. Tapan Kumar Gandhi. The work is also supported by the Prime Minister Research Fellowship awarded to Ms. Sapna S Mishra. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Data collection occurred under the purview of the Indian Institute of Technology Delhi, and all imaging procedures were conducted at Mahajan Imaging Center, New Delhi in accordance with the Institute Review Board (IRB) regulations. The pilot study was approved by the ethics committee of the Mahajan Imaging Center, and the entire study was approved by the Institute Ethics Committee, Indian Institute of Technology Delhi. All subjects provided informed consent before any behavioural or physical data was collected. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes
スペインの研究がロングコロナ患者65人の血液を解析し、免疫グロブリン（抗体）低下とSARS-CoV-2スパイク＆ヌクレオカプシド抗原の持続的な残存を質量分析で検出。症状が重いほど抗体低下＆ウイルス抗原多。新たなバイオマーカー候補も特定。診断や個別治療開発に重要な知見
2023年、米国では他の先進国の死亡率と比べて約70万人の「超過死亡」が発生。25〜44歳の死亡率は2.6倍に達し、65歳未満の死者のうち46%が「回避可能」と評価されました。COVID後も慢性疾患などが寿命に大きな影響。
