| web | https://urgeles.com |
| Place | Madrid, Spain |
We will reach a point where the concept of diagnosis will become obsolete. We will simply stop using it.
En la práctica médica, el diagnóstico es una herramienta fundamental que usamos para navegar en la complejidad de la salud humana. En el campo más concreto de la psiquiatría, el diagnóstico es una guía que nos permite identificar patrones de funcionamiento mental, de comportamiento y de respuesta emocional que no siempre son fácilmente visibles. Sin embargo, no podemos ignorar que...
CAR-T y glioblastoma
https://neurosciencenews.com/car-t-glioblastoma-brain-cancer-27694/
In yet another sign that bird flu is spreading widely among mammals, a new report finds more than half of cats at the first Texas dairy farm to have cows test positive for bird flu this spring died after drinking raw milk.
“quantum computing is a revolution that’s going to be bigger than fire and bigger than all the revolutions that humanity has seen”
Wonderful article that delves into the molecular depths of bipolar disorder with an initially counterintuitive idea but then clearly logical.
Evidence from diverse areas of research including chronobiology, metabolomics and magnetic resonance spectroscopy indicate that energy dysregulation is a central feature of bipolar disorder pathophysiology. In this paper, we propose that mania represents a condition of heightened cerebral energy metabolism facilitated by hyperglycolysis and glutaminolysis. When oxidative glucose metabolism becomes impaired in the brain, neurons can utilize glutamate as an alternative substrate to generate energy through oxidative phosphorylation. Glycolysis in astrocytes fuels the formation of denovo glutamate, which can be used as a mitochondrial fuel source in neurons via transamination to alpha-ketoglutarate and subsequent reductive carboxylation to replenish tricarboxylic acid cycle intermediates. Upregulation of glycolysis and glutaminolysis in this manner causes the brain to enter a state of heightened metabolism and excitatory activity which we propose to underlie the subjective experience of mania. Under normal conditions, this mechanism serves an adaptive function to transiently upregulate brain metabolism in response to acute energy demand. However, when recruited in the long term to counteract impaired oxidative metabolism it may become a pathological process. In this article, we develop these ideas in detail, present supporting evidence and propose this as a novel avenue of investigation to understand the biological basis for mania.
Science Scholar
RustyBertrand