ARF deficiency drives aggressive remodeling of the pancreatic cancer microenvironment, bypassing p53 pathways and enhancing treatment resistance.

by Ferreira S, Flowers BM (...) Attardi LD et 17 al. in Cancer Res

📖 read the article: https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-25-1969/775207/Inactivation-of-CDKN2AARF-Promotes-p53-Independent?redirectedFrom=fulltext

FET fusion oncoproteins compromise DNA repair mechanisms, highlighting ATR inhibitors as promising therapeutic targets for affected cancers.

by Gracilla DE, Menon S (...) Tulpule A et 18 al. in Cancer Res

📖 read the article: https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-25-2166/775208/FET-Fusion-Oncoproteins-Disrupt-Physiologic-DNA

Combined opioid or non-opioid therapies with ibuprofen fail to enhance pain relief in children with musculoskeletal injuries and increase adverse events.

by Ali S, Klassen TP (...) Poonai N et 10 al. in JAMA

📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2843665

Obesity drives 10% of annual cancer diagnoses in the U.S.; significant weight loss may lower associated cancer risk.

by Shen S, Brown KA, Green AK and Iyengar NM in JAMA

📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2846256

Bone Density Declines in RA Patients Despite Control of Disease Activity with DMARDs, Highlighting Need for Focused Osteoporosis Treatment.

by Aritomi T, Sonomoto K (...) Tanaka Y et 28 al. in Arthritis Rheumatol

📖 read the article: https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70125

Obesity triples the risk of severe infections and related deaths globally, responsible for an estimated 10% of infection-related fatalities.

by Nyberg ST, Frank P (...) Kivimäki M et 9 al. in Lancet

📖 read the article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02474-2/fulltext

Obinutuzumab significantly outperforms placebo in improving outcomes for adults with active systemic lupus erythematosus, enhancing disease management.

by Furie RA, Dall'Era M (...) Askanase AD et 22 al. in N Engl J Med

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2516150

Recognizing mid- and low-rectal cancers as distinct entities could transform treatment strategies, enhancing outcomes and quality of life for patients.

by Noiret B, Perez RO (...) Denost Q et 8 al. in J Clin Oncol

📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01861

New classifier identifies nasopharyngeal carcinoma metabolic subtypes, predicting enhanced event-free survival with anti-PD-1 immunotherapy in certain patients.

by Huang SW, Liang YL (...) Liu N et 19 al. in J Clin Oncol

📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-02111

Tumor-derived IFN reprograms macrophage niches, driving resistance to PARP inhibitors; targeting SPP1 could enhance treatment outcomes.

by Liu D, Tao K (...) Gao Q et 19 al. in J Clin Invest

📖 read the article: https://www.jci.org/articles/view/199035