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Hospitals capitalize on oncology biosimilars; acquisition costs drop significantly while reimbursement rates enable higher profit margins and increased utilization.
by Robinson JC, Kosorukov AD and Whaley CM in JAMA
📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2846346
Elevated serum phosphorylated tau levels indicate potential diagnostic utility in distinguishing AL and ATTR amyloidosis from other neuropathies.
by Kaeser SA, Schultz SA (...) Jucker M et 13 al. in Nat Med
📖 read the article: https://www.nature.com/articles/s41591-026-04272-2
Elevated serum levels of phosphorylated tau are not specific to Alzheimer’s disease and may also serve as a diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies.
Antibiotic use impacts gut microbiome diversity for years, with clindamycin and fluoroquinolones driving the most significant changes.
by Baldanzi G, Larsson A (...) Fall T et 17 al. in Nat Med
📖 read the article: https://www.nature.com/articles/s41591-026-04284-y
Using individual-level data from the Swedish Prescribed Drug Register and fecal metagenomes of 14,979 individuals in Sweden, the authors examined the association between oral antibiotic use over 8 years and gut microbiome and found evidence that antibiotics can have long-lasting impacts on the gut microbiome.
DGAT1 inhibition triggers ferroptosis, boosting cancer immunotherapy efficacy by enhancing T cell infiltration and reducing lipid accumulation.
by Pan D, Jiao M (...) Li CY et 4 al. in Cancer Res
📖 read the article: https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-25-0840/775226/DGAT1-Inhibition-Induces-Ferroptosis-and-Enhances
Abstract. Ferroptosis, a form of regulated cell death driven by lipid peroxidation, has emerged as a promising mechanism in cancer therapy. However, the lack of clinically viable ferroptosis inducers has precluded its therapeutic evaluation in patients. Here, we demonstrated that inhibition of diacylglycerol O-acyltransferase 1 (DGAT1) induces a ferroptosis-like phenotype in cancer cells and enhances the efficacy of immune checkpoint blockade (ICB) therapy. In human cancer cohorts, low DGAT1 expression correlated with improved prognosis and elevated ferroptosis-associated gene signatures. In murine models, both genetic knockout and pharmacological inhibition of DGAT1 enhanced ICB therapy efficacy by promoting increased infiltration of cytotoxic T lymphocytes (CTLs). Mechanistically, DGAT1 inhibition reduced lipid droplet (LD) accumulation, triggering elevated lipid peroxidation, mitochondrial dysfunction, and reactive oxygen species (ROS) production. These events culminated in glutathione peroxidase 4 (GPX4) depletion and ferroptosis. Given the availability of clinical-stage DGAT1 inhibitors, these findings provide a strong rationale for repurposing these agents as ferroptosis inducers to improve responses to cancer immunotherapy.
ARF deficiency drives aggressive remodeling of the pancreatic cancer microenvironment, bypassing p53 pathways and enhancing treatment resistance.
by Ferreira S, Flowers BM (...) Attardi LD et 17 al. in Cancer Res
📖 read the article: https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN-25-1969/775207/Inactivation-of-CDKN2AARF-Promotes-p53-Independent?redirectedFrom=fulltext
FET fusion oncoproteins compromise DNA repair mechanisms, highlighting ATR inhibitors as promising therapeutic targets for affected cancers.
by Gracilla DE, Menon S (...) Tulpule A et 18 al. in Cancer Res
📖 read the article: https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-25-2166/775208/FET-Fusion-Oncoproteins-Disrupt-Physiologic-DNA
Combined opioid or non-opioid therapies with ibuprofen fail to enhance pain relief in children with musculoskeletal injuries and increase adverse events.
by Ali S, Klassen TP (...) Poonai N et 10 al. in JAMA
📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2843665
Obesity drives 10% of annual cancer diagnoses in the U.S.; significant weight loss may lower associated cancer risk.
by Shen S, Brown KA, Green AK and Iyengar NM in JAMA
📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2846256
Bone Density Declines in RA Patients Despite Control of Disease Activity with DMARDs, Highlighting Need for Focused Osteoporosis Treatment.
by Aritomi T, Sonomoto K (...) Tanaka Y et 28 al. in Arthritis Rheumatol
📖 read the article: https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70125
Obesity triples the risk of severe infections and related deaths globally, responsible for an estimated 10% of infection-related fatalities.
by Nyberg ST, Frank P (...) Kivimäki M et 9 al. in Lancet
📖 read the article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02474-2/fulltext
