Our latest article on targeting lipid–protein interaction(LPI) to treat Syk-mediated AML is now published in @nchembio. We report a novel strategy of targeting LPI that can overcome the problems of MDR. Our study addresses these issues with the current targeting strategies and demonstrates the successful development of a clinically active LPI inhibitor. nature.com/articles/s41589-022... #research #drugdesign #oncology #nature #phd

Our collaborative work on ABCA7 is now online in EMBOJ https://lnkd.in/gwEh5QHY Owning to their role in in membrane homeostasis and lipoprotein generation, ABCA are of tremendous biomedical relevance. Here we combined cryoEM, microsecond long CGMD and functional assays to provide atomic details on the functions of ABCA7. Our CGMD simulations shows lipid partitioning into the ABCA7 and local membrane perturbations that underlie ABCA7 function. #cryoem #drugdevelopment #membranes #lipids #research