Oli

@olisuritz
11 Followers
27 Following
343 Posts
Staff Front-end Engineer
@carnage4life it’s the same stuff the book Nudge is about and that led to most workplace enrolling 401k participants by default instead of opt-in. Defaults are powerful because most people won’t change ‘em.

American Airlines pilots secured a 46% raise over the next four years. United Airlines pilots got a 40% raise. Delta pilots got 34% by 2026.

All this after the UPS settled with huge gains and soon SAG/WGA.

The workers are striking back and years of the only mouths being fed being shareholders and CEOs being are being overturned. Ever so slightly.

Yesterday, the best news which has ever come out during my lifetime, did. There's going to finally be an HIV cure. It's a ways down the road, but this all but guarantees it.

https://medicalxpress.com/news/2023-08-treatment-based-gene-safely-effectively.html

Here's the original paper explaining what was done in detail. Again, it's going to be a few more years before this is on the shelf, but there's finally hope for the end of HIV.

https://www.nature.com/articles/s41434-023-00410-4

Here's one of the two papers where the technology germinated about a decade ago. Note that the last paper was SIV instead of HIV, but it's such a good model, it almost always translates to humans.

https://www.nature.com/articles/nbt.2647

Here's the other one. If you don't like reading original source materials like this, or want to read the first announcement with the details on the good news, I'll sum up...

https://www.nature.com/articles/nbt.2623

This is a gene therapy which inactivates HIV/SIV by entering the virus itself and editing the genome. This is cool in and of itself, but it is meaningful because it does a thing called "draining the viral reservoir". This is what makes it a cure and not just a treatment.

The reason why you can only suppress, and not eradicate viruses, is because they will go into a dormant state and hang out for years and then re-deploy, and you're back where you started.

This is why, as amazing as antivirals are, you're generally stuck taking them forever.

This is also why Sovaldi is such a big deal: it actually *cures* Hepatitis C, which previously was only treatable. You take it (along with other things) for twelve weeks, and at the end you are free of the virus. This is a first. No other cures for viruses exist.

And now there's a method to drain the viral reservoir and inactivate HIV. And this isn't just the best news of my lifetime, but it also paves the way for therapies to cure Hep B, and any number of others.

I am so excited, so happy, so hopeful.

✨💖✨

Novel treatment based on gene editing safely and effectively removes HIV-like virus from genomes of non-human primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV—a virus related to the AIDS-causing agent HIV—from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report. The groundbreaking work complements previous experiments as the basis for the first-ever clinical trial of an HIV gene-editing technology in human patients, which was authorized by the Food and Drug Administration (FDA) in 2022.

Medical Xpress
It’s funny how tech billionaires used to be liberal and woke then they got bored with the act and took their masks off.
@carnage4life they never tweeted because the API was shut down 🥸

This has mostly been reported as "trans women banned from women's chess" but it's much more sinister. (as if it weren't already.)

ALL trans people are targeted by this ruling. Trans men will be stripped of all chess titles won, which can only be returned to them by “changing the gender back to a woman” (from the ICF’s ruling). ALL transgender chess players will be marked as trans in their files.

If you play or know anyone who does take a stand on this. It's ugly.

https://www.erininthemorning.com/p/international-chess-org-trans-women?utm_source=substack&utm_medium=email

International Chess Org: Trans Women Have "No Right To Participate" In Women's Chess

International Chess Federation, FIDE, has released new guidelines targeting transgender players. The guidelines would strip trans men's titles, and potentially bar trans women from playing.

Erin In The Morning
Some COVID minimizers keep saying we can ignore COVID because we have vaccines. Not only is that untrue because layers of protections are most effective, but due to the end of the public health emergency, and greed of pharma companies, many people can't even afford the vaccines.
@carnage4life “edge case”, “cannot reproduce”. Closed.
@carnage4life with a little bit of design (right branding like colors and fonts), you could have small “flyers” that you tape to some bank branches advertising their website and basically dupe users into entering their banking info (with maybe a legit redirect to the bank website after capturing the credentials).

A great example that “average” is often way less relevant than “median”.

From: @carnage4life
https://mas.to/@carnage4life/110893856222574805

Dare Obasanjo (@[email protected])

Attached: 1 image The average US president has been charged with 2 felonies.

mas.to