UC Davis Mouse Biology

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The UC Davis Mouse Biology Program (MBP) is an academic resource providing scientific expertise in the use of genetically modified mice for biomedical research.
Mouse ModelLarge selection of genetically modified mice
Research AssistanceAssist in models needed for any research project
PhenotypingComprehensive testing abilities to fulfill research requirements
Custom MiceUnique model creation options to better connect research to human connected conditions

@StanfordMed's research unveils ecDNA's role in cancer formation, intensifying the transformation of pre-cancer cells. Mouse Biology Program can help find a suitable model for further ecDNA studies!

scitechdaily.com/stanford-medicine-reveals-tiny-dna-circles-defying-genetic-laws-drive-cancer-formation

We need your help! We could use nominations for the next round of genes to knock out, study, and prepare for researchers.

Share the gene you'd like us to work on next here: projects.mousebiology.org/nominate.php

Think about all the mouse DNA that could be there too... (Scientists discover high-quality human DNA in the environment, including the air)

https://scitechdaily.com/unseen-trails-your-dna-can-now-be-collected-from-beach-sand-or-even-the-air/

Unseen Trails: Your DNA Can Now Be Collected From Beach Sand or Even the Air

University of Florida researchers found high-quality human DNA in nearly all environments, suggesting potential applications in fields like medicine, archaeology, and criminal forensics. However, this raises significant ethical concerns around consent and privacy, underscoring the need for guideline

SciTechDaily

Lack of amino acids during development can cause long-term changes, similar to autism. How this occurs was not studied, but it leads to possible add'l studies.

genengnews.com/developmental-disorders/autism/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors

TAD boundary sequences are essential for proper genome function - or "fences" in the genome.

nature.com/articles/s42003-023-04819-w

🧬🎉Happy #DNADay! Today we celebrate the incredible discovery of the DNA structure & its impact on science!

By studying mouse DNA, we unlock the secrets to human health, unravel complex diseases & fuel medical breakthroughs! 🧬🐁

Similar to our genetic outcome analysis in mice, this article gives insight into how Medical Providers should be examining patients' genomes. What do you think?

https://www.genomeweb.com/informatics/genomics-precision-medicine-command-larger-presence-himss#.ZEbhMHbMIuU

Genomics, Precision Medicine Command Larger Presence at HIMSS

HIMSS CEO Hal Wolf suggested that genotyping will soon supplant family history-taking at primary care visits, but EHRs and reimbursement policies haven't caught up.

GenomeWeb

New opportunity for cancer research: "The study shows that the EBNA1 viral protein binds to a fragile site on human chromosome 11."

https://scitechdaily.com/breaking-bad-how-a-virus-infecting-90-of-the-worlds-population-unleashes-cancer/

Breaking Bad: How a Virus Infecting 90% of the World’s Population Unleashes Cancer

The ubiquitous Epstein-Barr virus targets “fragile DNA,” triggering dysfunction that is associated with a variety of cancers. Researchers have discovered how the Epstein-Barr virus (EBV) exploits human genomic weaknesses to cause cancer and suppress the body's defenses. The study shows that the E

SciTechDaily

🔦 Like looking at illumination at a flashlight vs. a candle, long-read sequencing tends to show more about cancer genomics and could help examine cancer in a different light. (Not to mention, 🐁 research was referenced)

scitechdaily.com/the-long-read-for-cancer-a-new-broader-genomic-view

New 🐁 studies available after machine learning 👀💻 analysis find 4 distinct autistic subtypes. Research opportunities could help with gene pathway connections and treatment options 👩

DOI: 10.1038/s41593-023-01259-x