I've always been somewhat skeptical about bifunctional modalities due to their "expected" poor PK/PD, but many molecules surprised me with their superior efficacy despite their bizarre shape, and now we got some clues - groundbreaking work from Kevan Shokat https://www.science.org/doi/10.1126/science.abl5829?fbclid=IwAR3dcVV3yOQw-AiSKmKYIC7gXhEULgBjEwlDayEnxQlHCuBfFoi-2lwDXXQ

If you missed an excellent seminar by Mikko Taipale, you can watch it on our YouTube channel! No better way to spend your Thanksgiving break🦃 
https://youtu.be/weL6Wh01ViQ
Happy Thanksgiving!

Check out one of our recent webinars from Lindsey James (UNC-Chapel Hill) up now on YouTube!
"Altering the H3 methylation landscape through degradation of methyl-lysine reader proteins" https://www.youtube.com/embed/MAfXODlYDS0

Live webinar this Thursday - 11/17! One of the unsolved questions in the field is how to prioritize the E3s for TPD/TPS applications, and this ORFeome screen provides a comprehensive roadmap to address this. Tune in this week if you’re interested!

If you missed our TPD webinar with Michael Erb at Scripps Research Institute, you can catch it on our YouTube page! https://www.youtube.com/watch?v=yKfol2oqxoI