I've always been somewhat skeptical about bifunctional modalities due to their "expected" poor PK/PD, but many molecules surprised me with their superior efficacy despite their bizarre shape, and now we got some clues - groundbreaking work from Kevan Shokat https://www.science.org/doi/10.1126/science.abl5829?fbclid=IwAR3dcVV3yOQw-AiSKmKYIC7gXhEULgBjEwlDayEnxQlHCuBfFoi-2lwDXXQ

If you missed an excellent seminar by Mikko Taipale, you can watch it on our YouTube channel! No better way to spend your Thanksgiving break🦃 
https://youtu.be/weL6Wh01ViQ
Happy Thanksgiving!

Check out one of our recent webinars from Lindsey James (UNC-Chapel Hill) up now on YouTube!
"Altering the H3 methylation landscape through degradation of methyl-lysine reader proteins" https://www.youtube.com/embed/MAfXODlYDS0

Live webinar this Thursday - 11/17! One of the unsolved questions in the field is how to prioritize the E3s for TPD/TPS applications, and this ORFeome screen provides a comprehensive roadmap to address this. Tune in this week if you’re interested!