Just published: Engineering infrared light detection in blind human retina using ultrasensitive human TRPV1 channels.
Guilherme Testa-Silva
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Erkennen was die Welt Im Innersten zusammenhält.
Work by Morgan Chevalier, Firas Fadel, Tímea Májer , Daniel Magda, Ferenc Kilin, Lili Gerendas and in collaboration with the labs of Zoltan Z Nagy, Szabo Arnold, and
Botond Roska.
Botond Roska.
tl;dr: We trimmed human TRPV1 so it wakes up at ~41°C. Brief near‑IR “warm‑pulses” made ganglion cells in blind human retina explants fire graded spikes—no opsins, no nanoparticles, just AAV + human protein. Early‑stage, clean thermal control.
https://www.sciencedirect.com/science/article/pii/S016777992500318X
https://www.sciencedirect.com/science/article/pii/S016777992500318X
Hello Mastodon, , our first preprint on vision restoration is online:
https://www.biorxiv.org/content/10.1101/2025.01.08.631889v1
https://www.biorxiv.org/content/10.1101/2025.01.08.631889v1
Here is a schematic representation of a Fourier-transform infrared (FTIR) spectrometer (ChatGPT 4o)
