@BenjaminHCCarr

quote from article:
"Notably, 10 of the 19 individuals who reported that they were pregnant when exposed [to tear gas] reported a subsequent miscarriage — that’s about twice the expected rate of miscarriage. "

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tear gas (2-chlorobenzalmalononitrile [CS]) targets TRPA1

pepper spray (oleoresin capsicum [OC], capsaicin) targets TRPV1

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"Although TRPV1 and TRPA1 have been shown in the human eutopic and ectopic endometrium, their regulation and functional importance are not known..."
https://doi.org/10.1530/JME-15-0184

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"CS exposure induced strong tissue swelling, plasma extravasation, and a dramatic increase in inflammatory cytokine levels in the mouse ear skin. We also showed that the effects of CS were not transient but caused persistent skin injuries. These injury parameters were reduced with TRPA1 inhibitor treatment. Further, we tested the pharmacologic activity of advanced TRPA1 antagonists in vitro. Our findings showed that TRPA1 is a crucial mediator of CS-induced nociception and tissue injury and that TRPA1 inhibitors are effective countermeasures that reduce key injury parameters when administered after exposure. "
https://doi.org/10.1124/jpet.123.001666

#TRPchannels #nocicieption
#TearGas

I should probably mention that like the woman in 1st case report, I also have MCAS symptoms, as well as other pain and paresthesia in my hands and elsewhere. I had a colonoscopy a few months after this started and for the prep I ate mostly just white rice and tapioca - no fruit or veg. I felt much, much better on the colonoscopy prep diet. Since then my diet has become quite restricted as I noticed more pain when I ate cruciferous veg, alliums, legumes - lots of stuff.

So it is possible some of my erythromelalgia symptom improvement is due to having a limited diet - which is probably not so great for long term health overall.

I have wondered if there is TRP channel involvement since isothiocyanates and other food components can activate TRP channels, as can heat exposure.

Then there is the possibility of a connection to mast cells to consider.

#TRPchannels #MCAS #erythromelalgia