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✨Exciting news! Our research on parallel decision computations is out today in @NatureNeuro !
https://www.nature.com/articles/s41593-023-01305-8
There are often multiple strategies to solve a problem but we can only use one strategy at a time. Does this mean that the brain focuses on the executed strategy? How does it choose which strategy to compute?
In our new paper, we provide a surprising answer to these questions.
We found that rather than committing to a single strategy, the brain can compute multiple alternative decision strategies simultaneously!
Why would it be useful to represent both used and unused strategies simultaneously in the same brain region?
This property could facilitate cognitive flexibility and learning since changing strategies may only require selecting a precomputed decision variable rather than having to construct it from scratch.
Big thanks to my co-authors, especially Zach Mainen and Alfonso Renart for this great collaboration, and to the reviewers who definitely helped us improve this work!
How does the brain define a useful decision variable (DV) when many possibilities are available? The authors show that rather than committing to the DV used to solve the task, the mouse’s premotor cortex entertains several strategies in parallel.
JOB alert 🔔
We have a fully funded postdoctoral position (initially for 3 years; extension possible) to fill. Excited about systems neuroscience and natural social/sexual behaviors? Apply and come work with me!
Find the full advert and all details here:
https://ovgu.b-ite.careers/jobposting/2d7a31eb969a7b39578d7d842ba3fce211a7b0040
Please spread the word to those who might be interested!
We have an open position for a Research Associate at the Allen Institute for Neural Dynamics. Come join our exciting research environment. Please share!
https://alleninstitute.hrmdirect.com/employment/job-opening.php?req=2337381
Research Associate I Neurophysiology of decision making The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health Using an open science multi scale team oriented approach the Allen Institute focuses on accelerating foundational research developing standards and models and cultivating new ideas to make a broad transformational impact on science The mission of the Allen Institute for Neural Dynamics is focused on fundamental discoveries in systems neuroscience We are interested in how the brain builds our understanding of the complex world to guide the flexible behaviors that address our biological needs The answers will be in terms of defined neuron types and circuits interacting across the whole brain and body We will develop next generation methods and theories and employ a team based approach for discovery neuroscience Knowledge data models and tools will be widely shared in part to support the development of therapies for brain disorders We are seeking a Research Associate to contribute to a project to uncover the functions of neuromodulators eg serotonin norepinephrine dopamine and networks in the frontal cortex basal ganglia and thalamus during dynamic decision making in mice The ideal candidate will be team oriented have knowledge in neuroscience and behavior and a strong interest in studying brain wide circuits during behavior This position will leverage state of the art behavioral computational electrophysiological and imaging methods as well as molecular and transgenic resources The goal is to make fundamental discoveries about identified cell types within brain circuits during flexible decision making The Allen Institute believes that team science significantly benefits from the participation of diverse voices experiences and backgrounds Progress in science benefits from multiple perspectives We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role Essential Functions Perform experiments involving in vivo cell type specific electrophysiology neural manipulations and carefully controlled mouse behaviorCollaborate with scientists and engineers to develop and evaluate methods for data collection quantification and analysisTrain team members to perform proceduresCollaborate internally and externally to analyze physiology and behavior dataNote Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned Required Education and Experience Bachelors degree in Neuroscience Biology or related disciplinePreferred Education and Experience 2 years of experience in a laboratory settingPractical experience in in vivo electrophysiology and behaviorAbility to write reusable code in Python or Matlab Work Environment Will work in laboratory environment including potential exposure to lasers biohazardsAnimal Care Services Exposure to and handling of laboratory animals required dailyPre and post operative care for miceAdministration of compounds to mice iv ip sc po im ro icvPerform health assessments of micePerform euthanasia and tissue collectionsPerform daily vivarium maintenance andor closing proceduresPhysical Demands Fine motor movements in fingershands to operate computers and other office equipment; repetitive motion with lab equipmentStooping bending crouching Reaching or climbing laddersPosition TypeExpected Hours of Work Occasional evening and weekend hours requiredThis role is currently working onsite and is expected to work onsite for the majority of working hours The primary work location for this role is 615 Westlake Ave N with flexibility to work remotely on a limited basisAdditional Eligibility Qualifications In keeping with our focus on employee safety all employees must be up to date with vaccinations against COVID 19 as a condition of employment unless a medical or religious accommodation is approved All employees will be required to keep their vaccination status up to date according to CDC guidanceAnnualized Salary Range 46708 65392 Final salary depends on required education for the role experience and level of skills relevant to the role along with work location where applicable Benefits Employees and their families are eligible to enroll in benefits per eligibility rules outline in the Allen Institutes Benefits Guide These benefits include medical dental vision and basic life insurance Employees are also eligible to enroll in the Allen Institutes 401k plan Paid time off is also available as outlined in the Allen Institutes Benefits Guide Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide httpsalleninstituteorgcareersbenefitsIt is the policy of the Allen Institute to provide equal employment opportunity EEO to all persons regardless of age color national origin citizenship status physical or mental disability race religion creed gender sex sexual orientation gender identity andor expression genetic information marital status status with regard to public assistance veteran status or any other characteristic protected by federal state or local law In addition the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities
Job alert: tenure-track Assistant Professorship in Applied Psychology! 📢
My department at Leiden University is recruiting an Assistant Professor in Applied Cognitive Psychology, with tenure after 1.5 years. Research topics include behavior change and sustainability, and the position includes teaching and coordinating our MSc program. Deadline is 10 February, apply here.
The section Cognitive Psychology of the institute Psychology of the Faculty Social and Behavioural Sciences is looking for a Assistant Professor in Applied Cognitive Psychology (1,0 FTE) Vacancy number 22-027 13343 We are looking for an assistant professor who is willing and able…
Open PhD positions available with @Ranczlab and myself
Neuromodulatory mechanisms of predictive processing in the mouse visual cortex
🔎 Mor information at https://centuri-livingsystems.org/phd2023-14/
⚠️ Deadline for application and for recommendation letters: February 16, 2023
Neuromodulatory mechanisms of predictive processing in the mouse visual cortex Host laboratory and collaborators Ede Rancz (INMED) / [email protected] Laurent Perrinet (INT) / [email protected] Abstract The predictive processing framework is considered a universal principle in the operation of the brain(1). However, how it is implemented on the level of circuits and single neurons is an…